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ANTI-INFLAMMATORY AGENTS
专利权人:
发明人:
申请号:
HK12102789.7
公开号:
HK1162314A
申请日:
2012.03.20
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The invention provides compounds, pharmaceutical compositions and uses of compounds of general formula (I) or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein z is 1, 2 or 4 X is -CO-Yk-(R<1>)n or SO2-Yk-(R<1>)n k is 0 or 1 Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group) or is a cycloalkenyl or polycycloalkenyl group each R<1> is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms (for example of 5 to 20 carbon atoms, of 8 to 20 carbon atoms, of 9 to 20 carbon atoms, of 10 to 18 carbon atoms, of 12 to 18 carbon atoms, of 13 to 18 carbon atoms, of 14 to 18 carbon atoms, of 13 to 17 carbon atoms) or each R<1> is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y (such that n=1 if k=0, such that the R<1> group is bonded directly to the carbonyl or sulfonyl group) provided that simultaneously X cannot be an undec-10-en-l-oyl group and z be equal to 1 or 2 or alternatively R<1> is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.
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