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Fluorine-substituted cyclic amino compounds and methods for their preparation, pharmaceutical compositions and their use
专利权人:
ЧАЙНИЗ ЭКЭДЕМИ ОФ САЙЭНСИЗ (CN);ШАНХАЙ ИНСТИТЬЮТ ОФ МАТИРИА МЕДИКА
发明人:
ЛЮ Хун (CN),ЧЖАН Хайянь (CN),ЧЖОУ Юй (CN),ФУ Янь (CN),ЦЗЯН Хуалян (CN),ТАН Сицань (CN),ЧЭНЬ Кайсянь (CN)
申请号:
RU2015114721
公开号:
RU2015114721A
申请日:
2013.10.17
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A fluoro-substituted cyclic amino compound of the general formula I, its racemate, R-isomer, S-isomer and a pharmaceutically acceptable salt or a mixture thereof: general formula I, where m is an integer from 0 to 3, where m is preferably 0, 1 or 2; n is an integer from 0 to 3, where n is preferably 0, 1 or 2; X is (CH), CO or SO, where p is an integer from 0 to 3; R is a substituted or unsubstituted C -Cycloalkyl, substituted or unsubstituted C-cycloalkenyl, substituted or unsubstituted 3-12 membered heter a cyclic group, a substituted or unsubstituted C-Caril; the substituent (s) R represents (1) 2, 3, 4 or 5 identical or different substituents independently selected from the group consisting of halogen, C-C1-6alkyl, halogen-substituted C-C1-6alkyl, C-C1-6 alkoxy, C-alkoxycarbonyl, halogen-substituted C-Salkoxy, C-Salkenyl, C-Salkynyl, C-Cycloalkyl, cyano, nitro, amino, hydroxyl, hydroxymethyl, carboxyl, mercapto, sulfonyl, C-Saryl and a 3-12 membered heterocyclic radical; or two adjacent C-Saryl substituents and the carbon atom (s) of the adjacent aromatic ring together form a C-Cycloalkyl, C-Cycloalkenyl or a 3-7 membered heterocyclic radical; and each heterocyclic radical independently contains from 1 to 4 heteroatoms selected from O, S or N; each of R and R is independently selected from the group consisting of hydrogen, carboxyl, C-C1-6 alkoxycarbonyl and C-C1-6 alkyl; or R and R together form C-C1-6alkylidene; R1 represents from 1 to 4 identical or different substituents selected from the group consisting of hydrogen, halogen, C-C1-6alkyl, halogen-substituted C-C1-6alkyl, C-Salkoxy, halogen-substituted C-Salkoxy, C-Salkenyl , C-alkynyl, cyano, nitro, amino,1. Фторзамещенное циклическое аминосоединение общей формулы I, его рацемат, R-изомер, S-изомер и фармацевтически приемлемая соль или их смесь:общая формула I,где m представляет собой целое число от 0 до 3, где m предпочтительно равен 0, 1 или 2;n представляет собой целое число от 0 до 3, где n предпочти
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