Near infrared imaging is highly complementary to colour imaging having a widerange of applications For example,in health applications, the near infrared can provide biomolecular informationon tissue that is not apparent under visual examinationnor from the inspection of colour images of tissue Thus, there is utility inviewing both visible color and near infrared images incombination. Described herein are methods to perform visible and near infraredimaging as well as hybrid visible color and near infraredimaging with a single conventional color filter array RGB sensor The methodsautomatically provide spatially co-registered color andnear infrared images and the methods can be used as the basis for amultispectral or hyperspectral imaging system.