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Composés de spiro-oxindole et leurs utilisations en tant qu'agents thérapeutiques
专利权人:
XENON PHARMACEUTICALS INC.
发明人:
申请号:
EP11009687.2
公开号:
EP2428515B9
申请日:
2006.04.11
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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