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2-6 Polymorphic Compounds and Their Use as Canning Inhibitors
专利权人:
NOVARTIS AG
发明人:
TCHORZ, JAN,MAIBAUM, JUERGEN KLAUS,LEE, CAMERON,ZOU, YEFEN,YAN, SHANSHAN,XIE, YUN FENG,PAN, JIANFENG,QU, XIN,MO, TINGTING,LIU, YAHU A.,LIU, JUN,LACOSTE, ARNAUD,JIN, QIHUI,HOFFMAN, TIMOTHY Z.,HAO, XUES
申请号:
ARP180101055
公开号:
AR111421A1
申请日:
2018.04.25
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
Claim 1: A formula compound (1),Salt or its stereoisomers are characterized by X1 being CH or N; Ring A is a single-ring anomaly consisting of five or six members, connected with other molecules through a carbon ring member, as a ring member, consisting of one to four selected anomalous atoms. NON is independent of N, or Y and S, provided that at least one heteroatomic ring member is a non-replaced nitrogen (-N=), located at position 3 or 4, relative to the position of the heteroatomic ring member or ANI of five members. Mr. llo, six non-orthodox members;O(b) Double-cycle special-shaped capacitors with nine members selected from formula compound (2),Among them, *"refers to the binding point between ring A and other molecules, and in ring A, it has not been replaced or replaced by one or two substitutes without halogen, cyanide or alkyl C832183316C.Halogenated tar C832183531832626,- NH832222,Rent C832121;Di-(Acquilo C83216C833183226) Amino, cycloquilo C8323131;E. phenylsulfonyl; R830404 is hydroxyl or alcoxilo C832183318326;R1 is hydrogen or C83218331832626;R2. Selected from (a) C8321833183288A asphalt, it was not replaced or replaced by one or three alternatives independent of (i) halogen; (i) cyanide; (i) Oxo; (iv) Alquenilo C8322833183266;(v) C83228331832626 asphalt;(vi) Haloglio C83213531832626;(vii) Or8310 - In which R8310A chooses C83218331836262 from hydrogen without being replaced or replaced by R830404;(viii) - No. 8311; No. 7491; No. 8311; No. 74955;Among them, R8311 and 74919 are hydrogen or C83218331832626;R8311 and R74955 were selected from hydrogen, -C(O) R830404;No. E. C83218331832626 need not be replaced or replaced by - C (O) R830404.(ix) - C(o) R831222;E.R831222 is R83040 O-NH-C8321883318326; "Acquilo-C(o) R830404;(x) S (o) 83222-C83218C83316262;(xi) Cyoquilo C832318331832626 or cyclopropyl compound C83278321838331838383838383838321; 8320 Policic, each of which is replaced or replaced by halogen substitutes C832183326262 selected independently by 1-
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