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Pirimidinona FUSED substituted compounds
专利权人:
TORRENT PHARMACEUTICALS LIMITED
发明人:
ABRAHAM, JAYA,MISHRA, VIVEK,DESHPANDE, SHAILESH,JAMADARKHANA, PRASHANT,RAI, DEEPAK,GUPTA, RAMESH CHANDRA,TULI, DAVINDER,SRIVASTAVA, SANJAY,RODE, MILIND,JOSHI, DEEPA,DUTT, CHAITANYA
申请号:
ARP170101057
公开号:
AR108327A1
申请日:
2017.04.26
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
1. Claim 1: a compound of formula (1), wherein X is a binding or other formula (2);*Represents the coupling point of ring a and other molecules; if x is a combination, ring a is a single ring or double ring heteromorphism with at least one n, and N is the coupling point of X; or if x is the rest of the formula (2),Ring a is arilo or monocyclic or bicyclic heretics; ring B is monocyclic or bicyclic arilo or heterosexual of 6 people; R1 and R2 are selected independently of hydrogen, halogen and no832222;Number 1CF8323,CN, COOR⁹,Cor8313,Or8313,Ocor8313,O-c832188331; 832626 tar or 831393;O-C alquil-S (O) RO-c832188331; 832626 asphalt-nr-1,1,O-C₁₋₆ alkyl-COOR⁹,O-C₁₋₆ alkyl-COR⁹,S (O) RC83218331;C alquil-S (O) RC₁₋₆ alkyl-NR¹¹R¹²,C₁₋₆ alkylaryl, C₁₋₆ alkylheteroaryl, C₁₋₆ alkylheterocycloalkyl, C₁₋₆ alkylcycloalkyl, C₂₋₅ alkenyl-R¹³,C₂₋₅ alkynyl-R¹³,heterocycloalkyl, aryl, boronate ester, and heteroaryl; said C₃₋₆ cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted by R¹⁰;R3 and r830808 are hydrogen independent,Halogen, 11,No.8322;CF8323,O-c832188331; 832626 tar or 831393;O-C alquil-S (O) RO-c832188331; 832626 asphalt-nr-1,1,O-C₁₋₆ alkyl-COOR⁹,O-C₁₋₆ alkyl-COR⁹,S (O) RCor8313,Coordination 8313,C83218331;e. C83328331-8326cyclo, isopropene, isopropene, arilo and isopropene, alternative to r183044;R83099,R8310,R831181 and r831222 are independent of hydrogen, halogen, NrCF8323,Coordination 8313,Cor8313,e. C83218331 and c832626 asphalt, or r830910 or r831181 and r831222 together, can form 3 to 6 members of single ring chemical ring; r8313 independent hydrogen selection;CF8323,SO₃H, glucuronate, C₁₋₆ alkyl, C₁₋₆ alkyl-R¹⁰,C₃₋₆ cycloalkyl, heterocycloalkyl, aryl and heteroaryl; that C₃₋₆ cycloalkyl, heterocycloalkyl, aryl and heteroaryl is optionally substituted by R¹⁰;R83044 is independent of hydrogen, oxo, halogen and cf.83323;S (O) ROr8313,No.8322;Cor8313,Coordination 8313,Number 1N (R) CORN (r8313) s (o) 8344r8313 and ocor8313;C83218331;C₁₋₆ alkyl-CO
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