This invention relates to a combination drug comprising a combination of a tetrazolylalkoxy-dihydrocarbostyril derivative of the formula: wherein R is cycloalkyl, A is lower alkylene, and the bond between 3-and 4-positions of carbostyril nucleus is single bond or double bond, or a salt thereof and Probucol, which is useful for preventing and treating cerebral infarction including acute cerebral infarction and chronic cerebral infarction, arteriosclerosis, renal diseases (e.g. diabetic nephropathy, renal failure, nephritis), and diabetes owing to synergistic superoxide suppressant effects of the combination.本發明係關於一種組合藥物，該組合藥物包括下式之四唑基烷氧基－二氫喹諾酮(tetrazolylalkoxy－dihydrocarbostyril)衍生物或其鹽，及普羅布考(probucol)之組合：；(1)；式中，R為環烷基，A為低碳數伸烷基，及在喹諾酮核之3及4位置間的鍵結係表示單鍵或雙鍵，其由於該組合之增效(synergistic)超氧化物抑制劑效應而可適用於預防及治療腦梗塞(包括急性腦梗塞急慢性腦梗塞)、動脈硬化、腎病(例如糖尿病腎病變、腎衰竭、腎炎)及糖尿病。
