DR. SZNT, GBOR,DR. SZONDIN KORDS, KRISZTINA,DR. SZELECZKY, ZSOLT,DR. BATA, IMRE
申请号：
ARP180103644
公开号：
AR113934A1
申请日:
2018.12.13
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
1. This substance refers to 5,6-dihydro-4h - [1,2,4] triazole [4] derivative； 3-a. [1] benzazepina (1) and / or its salts and / or geometric isomers and / or their stereoisomers and / or their corresponding isomers and / or their isomers and / or their racemates and / or their bioactive metabolites and / or their adults and / or their solutions and / or their hydrates and / or polymers, As a modulator of V1a receiver, it mainly acts against (or) the periphery, especially against the V1a receiver.It also refers to pharmaceutical components containing these compounds, or used in conjunction with one or more other effective principles, and in the treatment and / or prevention of diseases or diseases related to the function of V1a receptors. 1: The characteristic of compound (1) of equation is that ring a is a cyclopropyl group or a non cyclopropyl group； and-C（o）……-Ch832222-，-NH-O link, if ring B is there； o-n (c83218331838324)； renter) 832222；C (o) oc832183318324；； asphalt, c832183318324；； selective halogen substituted asphalt, c8321833838324；； halogen or halogen in the absence of ring B； ring B is an alternative arilo, isocyclic propylene or heteromorphic； or - Y-A - together represents 3H helix [2-benzofuran-1, 4 '- piperidin-1'； O formula group (2)；O formula group (3)；O formula group (4)；R1 is hydrogen, halogen, c832131；c（o）R83099；O c83218331； or, alternatively, leased land to be replaced by r8310；O R2 and R3 together represent a group of - (ch832222) - 8346； - O - (ch832222) q-o - (ch8322691 -)；R830808 is a CN, azida or cy1 group；R83099 is a c832183318324；； ogillo, c83218331838324；； alcox, oh o, nr8311；； r831222；R8310 is an or8313,No. 830404； R1,e. Oxo-o (ch8322)； O-O one or more halogens； r8311 and r831222 are independent hydrogen, c83321c83318324； pitch, cyo or r8311 and r831222 form a heterocycle with N； r831393 is a hydrogen； c83183318324；； asphalt with optional nh8322o or arilo group； c2383si (23838383832383)；O C (o) R2 group；R1 830404 and R1 are independent
