An operation support device includes a patient information acquirer that acquires patient information in which a patient ID, a symptom, a medical practice, and an instrument ID are associated with one another from an external device, an operation storage in which an operation instruction table in which the instrument ID, the symptom or the medical practice, and an operation instruction are stored in association with one another is stored, a medical instrument reader that reads the instrument ID assigned to the medical instrument, and a processor that extracts, based on the instrument ID that has been read by the medical instrument reader, the patient information, and the operation instruction table, an operation instruction in accordance with the symptom of the patient for whom or the medical practice in which the medical instrument with the instrument ID, which has been read by the medical instrument reader, has been used.