Vectors and methods for genetic immunization

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专利权人:

Nature Technology Corporation

发明人:

Williams, James A.

申请号：

AU2008262478

公开号：

AU2008262478B9

申请日:

2008.05.22

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

Improved DNA vaccine plasmids are disclosed that contain novel immunostimulatory RNAcompositions. The improved plasmids eliminate all extraneous sequences, incorporatea novel antibiotic free short RNA based selectable marker, increase eukaryoticexpression using a novel chimeric promoter, improve yield and stability duringbacterial production, and improve immunostimulation. These vectors are utilizedin immunization to elicit improved immune responses or therapy to induce type1 interferon production.

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