Jerrod Joseph SCHWARTZ,Krishnan Kanna PALANIAPPAN,Alberto Clemente VITARI
申请号：
US15083830
公开号：
US20160287152A1
申请日:
2016.03.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A nanoparticle conjugate includes a nanoparticle, first oligonucleotides of one or more types bound to the nanoparticle, each type of first oligonucleotide having a sequence, and targeting conjugates of one or more types, each type of targeting conjugate comprising a targeting entity and a second oligonucleotide bound to the targeting entity and having a sequence that is complementary to a sequence of a predetermined type of the first oligonucleotides, wherein the second oligonucleotide are covalently bound to a surface of the nanoparticle, a functional group on the surface of the nanoparticle, or one of the first oligonucleotide. Also provided are methods for making such nanoparticle conjugates and methods and devices for using such nanoparticle conjugates.
