University of Maryland, Baltimore;The Johns Hopkins University
发明人:
Graeme F. Woodworth,Jeffrey A. Winkles,Anthony J. Kim,Craig S. Schneider,Justin Hanes
申请号：
US15528555
公开号：
US20180185511A1
申请日:
2015.11.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are targeted structure-specific particulate-based delivery systems comprising: a nanoparticle； a PEG polymer coating on the surface of the nanoparticle； a targeting moiety conjugated on a surface of the nanoparticle and configured to promote specific binding to a cell surface molecule expressed by a target cell； and a biologically active agent in or on the nanoparticle, wherein the biologically active agent is selected to enhance a desired response in a target cell intracellularly or extracellularly. Methods of treating a disease or disorder administering the delivery system are contemplated.
