您的位置: 首页 > 农业专利 > 详情页

ИНГЕНОЛ-3-АЦИЛАТЫ III И ИНГЕНОЛ-3-КАРБАМАТЫ
专利权人:
LEO LEHBORETERIZ LIMITED
发明人:
GRUEH-SERENSEN GUNNAR,LJAN SIFU,KHEGBERT TOMAS,MONSSON KRISTOFFER,VEDSE PER,VIFIAN TOMAS,ГРУЭ-СЕРЕНСЕН Гуннар,ЛЯН Сифу,ХЕГБЕРТ Томас,МОНССОН Кристоффер,ВЕДСЕ Пер,ВИФИАН Томас
申请号:
RU2013133874
公开号:
RU2572549C2
申请日:
2011.12.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compound of general structural formulawhich can be used for prevention, treatment, relieving course or prevention of physiological disorders or diseases, associated with hyperplasia or neoplasia. In formula (I) R stands for 5-10-membered mono- or bicyclic heteroaryl, containing 1-3 heteroatoms, selected from O, N and S, which can be optionally substituted with one or more substituents, independently selected from R7, or R stands for 5-10-membered heterocycloalkyl, containing 1-2 heteroatoms, selected from O, N and S, or 5-10-membered heterocycloalkenyl, containing 1-2 heteroatoms, selected from O, N and S, where said 5-10-membered heterocycloalkyl or 5-10-membered heterocycloalkenyl are optionally substituted with one or more substituents, independently selected from R8; or R stands for X; R7 represents halogen; or R7 represents (C-C) alkyl, (C-C) alkenyl, (C) cycloalkyl, 6-membered heterocycloalkyl, containing 1 heteroatom, selected from N, C-aryl, C-aryl (C-C) alkyl, 6-membered heterocycloalkyl (C-C) alkyl, containing 1 heteroatom, selected from O, or (C) cycloalkyl (C-C) alkyl, where said (C-C) alkyl or C-aryl are optionally substituted with one or more substituents, independently selected from R9; or R7 represents -ORa; Ra represents (C-C) alkyl; Rc represents (C-C) alkyl; X represents -NR11R12, Rf represents (C-C) alkyl. Values of radicals R8-R13, Rd are given in the invention formula.EFFECT: invention relates to pharmaceutical composition, containing said compound, and to method of prevention, treatment, relief of course or prophylaxis of physiological disorders or diseases, associated with hyperplasia or neoplasia, responding to stimulation of neutrophil oxidative burst, stimulation of IL-8 release from keratinocytes and to necrosis induction.36 cl, 2 tbl, 753 exИзобретение относится к соединению общей структурной формулы I, которое может быть использовано для предотвращения, лечения, облегчения т
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充