Concomitant medications for the treatment of depression

• 收藏
• 分享

专利权人:

ザ ロックフェラー ユニバーシティ;学校法人;学校法人 久留米大学;学校法人日本医科大学;学校法人藤田学園;久留米大学

发明人:

西 昭徳,小林 克典,宮川 剛,グリーンガード，ポール,グリーンガード,ポール

申请号：

JP2013543442

公开号：

JP5828345B2

申请日:

2012.03.22

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention provides a combination medicine for treatment of depression, comprising a combination of (A1) an antidepressant and either (B1) a dopamine D1 receptor agonist or (C1) a dopamine D1 receptor antagonist； and a method for screening for an antidepressant that in combination with a dopamine D1 receptor agonist provides an improvement in treatment of depression, the method comprising the steps of: administering, to a mammal, (A2) a compound having an antidepressant action and (B1) a dopamine D1 receptor agonist, and detecting a greater increase in depression-related gene expression, dopamine D1 receptor expression and/or dopamine D1 receptor signaling in comparison with the case where (A2) the compound having an antidepressant action or (B1) the dopamine D1 receptor agonist is administered.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/