Bruce Ellsworth,Gang Wu,Philip M. Sher,Wei Meng,William N. Washburn
申请号：
BRPI0014722
公开号：
BRPI0014722B1
申请日:
2000.10.02
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
sglt2 inhibitor compounds, pharmaceutical composition and use of said compounds are provided sglt2 inhibitor compounds having the formula (i) wherein r1 and r2 are independently hydrogen, oh, or5, (C1-c8) alkyl, cf3, ochf2, ocf3, sr5i or halogen, or r1 and r2 together with the carbons to which they are attached form -och20-； R3 and R4 are independently hydrogen, oh, orsa 'ofenyl, och2phenyl, (C1 -C6) alkylcyclohexyl, cf3, -ochf2, -ocf3, halogen, -c02r5b, -c02h, cor6b, -ch (oh) r6c, - nhcor5c, -nhs02r5ct, -nhs02phenyl, phenyl, -srse '-sor5f, -s02r5g, -s02phenyl, thiadiazolyl, tetrazolyl, or r3 and r4 together form -och20-； R5, R5a, R5b, R5c, R5d, R5e, R5f, R5g and R5i are independently C1 -C8 alkyl； R 6b and R 6c are independently hydrogen or C 1-8 alkyl； a is o, s, nh, or (ch2) n where n is -3, or a pharmaceutically acceptable salt thereof or stereoisomer thereof； provided that where a is (ch2) n where n is o, 1, 2, or 3 or a is o, and at least one of r1 and r2 is oh or or5, then at least one of r1 and r2 is cf3, ocf3 or ochf2 and / or at least one of r3 and r4 and cf3, - ochf 2, - ocf 3, -co2r5b, ch (oh) r6c, cor6b, -nhcor5c, -nhso2r5d, -nhso2phenyl, phenyl, -sr5e , -sor5f, -so2r5g or -so2phenyl.compostos inibi dores de sglt2, composição farmacêutica e uso dos referidos compostos são fornecidos compostos inibidores sglt2 tendo a fórmula (i) onde r1 e r2 são independentemente hidrogênio, oh, or5 , alquila (c 1-c8 ), cf3 , ochf2, ocf3 , sr5i ou halogênio, ou r1 e r2 juntamente com os carbonos aos quais são ligados formam -och20-； r3 e r4 são independentemente hidrogênio, oh, orsa' ofenila, och2fenila, alquila ( cl -cs) i cicloexila, cf3, - ochf2, -ocf3, halogênio, -c02r5b, -c02h, cor6b, -ch (oh) r6c, -nhcor5c, -nhs02r5ct, -nhs02fenila, fenila, -srse' -sor5f, -s02r5g, -s02fenila, tiadiazolila, tetrazolila, ou r3 e r4 juntos formam -och20-； r5, r5a, r5b, r5c, r5d, r5e, r5f, r5g e r5i são independentemente alquila ( c1-c8) ； r6b e r6c são independentemente hidrogênio ou
