MCPHERSON JOHN,MEADE HARRY M,EDMUNDS TIMOTHY,SCHINDLER DANIEL
申请号：
NZ59535106
公开号：
NZ595351A
申请日:
2006.10.23
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
A composition comprising antibodies, wherein the antibodies have enhanced antibody-dependent cellular cytotoxicity (ADCC) activity, wherein the antibodies are from non-human mammalian mammary epithelial cells engineered to express the antibody, wherein the ADCC activity of the antibodies is enhanced at least two-fold compared to cell-culture derived antibodies, wherein the carbohydrates of the antibodies exhibit a high mannose glycosylation pattern, wherein at least 30% of the antibodies contain at least one oligomannose, and wherein the antibodies are of the isotype IgG1 or IgG2.
