EDMUNDS, TIMOTHY,MCPHERSON, JOHN,SCHINDLER, DANIEL,MEADE, HARRY M.
申请号：
DK06844220
公开号：
DK1945666T3
申请日:
2006.10.23
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.
