WAKE FOREST UNIVERSITY HEALTH SCIENCES;ZHANG, YUANYUAN;ATALA, ANTHONY
发明人:
ZHANG, YUANYUAN,ATALA, ANTHONY
申请号：
WO2008US06438
公开号：
WO2008153685(A2)
申请日:
2008.05.20
申请国别(地区):
世界知识产权组织国际局
年份:
2008
代理人:
摘要：
Provided herein are urine progenitor cells and methods for producing a culture of urine progenitor cells from a urine sample. The cells may be selected based upon the use of a selective cell medium, based upon morphology, and/or by selecting cell-specific markers. Also provided is an isolated urine progenitor cell that is c-kit positive and can differentiate into urothelium, smooth muscle, endothelium or interstitial cells. Methods of use of urine progenitor cells are provided, wherein cell are seeded onto a tissue scaffold are provided. Methods of treating a subject in need thereof are also provided, including providing a bladder tissue substrate that includes differentiated UPCs and transplanting the substrate into the patient. Finally, kits are provided that include a container suitable for the transport of a urine sample; media; one or more antibiotics; a package for holding said container, media, and antibiotics; and optionally, instructions for use.
