PROBLEM TO BE SOLVED: To obtain a HB-EGF gene expression promoter comprising a plant-derived component as an active ingredient. SOLUTION: The HB-EGF gene expression promoter comprises at least one kind selected from the group consisting of an extract of Angelica archangelica, extract of Stellera chamaejasme L., extract of Boswellia carterii Birdw., extract of Euphorbia kansui Liou, extract of Impatients balsamina L., extract of Forsythia suspensa Vahl., extract of Medicago sativa, extract of Commiphora myrrha Engl. (C. molmol Engl), extract of Stillingia sylvatica, extract of Lycopodium clavatum L., extract of Centipeda minima (L.) A. Br. et Aschers., extract of Cnidium monnieri (L.) Cuss., extract of Ficus carica L., extract of Magnolia lilifora Desr., extract of Magnolia denudate Desr., extract of Betula platyphylla Suk. Var. japonica (Sieb.) Belly and extract of Chenopodium hybridum L., as an active ingredient. COPYRIGHT: (C)2009,JPO&INPIT