Provided in the present invention is a compound represented by the following general formula (1), a pharmaceutically acceptable salt thereof, ester thereof or stereoisomer thereof. Also provided in the present invention also are a method for preparing the compound and a use thereof in the preparation of a drug for preventing/treating non-alcoholic fatty liver disease, primary biliary cirrhosis, lipid metabolic disorders, diabetic complications and malignancy. R1, R2, R3, R4, m, n, W, A, Z, E, F, X and Y are as defined in the description.本發明提供下述通式(1)所示的化合物、其藥學上可接受的鹽、其酯或其立體異構物,本發明還提供上述化合物的製備方法以及在製備用於預防和/或治療非酒精性脂肪肝、原發性膽汁性肝硬化、脂質代謝紊亂、糖尿病併發症及噁性腫瘤的藥物中的用途。其中,R1、R2、R3、R4、m、n、W、A、Z、E、F、X、Y如說明書中所定義。
