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PROCESS FOR PURIFYING 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID
专利权人:
AGFA Healthcare
发明人:
BUFFEL, Diederik,BOI, Xavier,PYPE, Judith
申请号:
EP20150702255
公开号:
EP3102566(A1)
申请日:
2015.02.02
申请国别(地区):
欧洲专利局
年份:
2016
代理人:
摘要:
includes the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts and hydrates thereof so as to obtain a slurry having a pH≦3; and b) filtering the slurry and at least one time washing the obtained precipitate with a liquid comprising water; and c) dissolving the precipitate obtained in step b) in water to obtain an aqueous solution; and d) filtering of the solution obtained in step c) over a nanofiltration membrane having a Molecular Weight Cut Off in the range from 150 to 500 and wherein optionally, between step c) and step d) the pH of the aqueous solution is adjusted to a pH value in the pH range as specified by the manufacturer of the nanofiltration membrane. A process for preparing a gadolinium complex of the purified compound of formula 1 is also disclosed. This gadolinium complex can be used for making a pharmaceutical composition as a contrast agent for magnetic resonance imaging.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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