KANG, XIAOQIANG,姜小强,姜小強,BALDERES, PAUL J.,布得斯 保罗Ｊ,布得斯 保羅Ｊ,布得斯 保罗J,布得斯 保羅J
申请号：
TW098107909
公开号：
TWI384997B
申请日:
2009.03.11
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention provides for fully human antibodies and chimeric antibodies that bind human TYRP1 antigen with an affinity comparable to or higher than TA99, a murine antibody specific to TYRP1. The invention further provides polynucleic acids and host cells that encode and express these antibodies. The invention also provides for methods of modulating activity of TYRP1, treating growth of a cancer cell, and treating a malignant melanoma in mammals by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment.本發明提供以相當於或高於TA99之親和力結合人類TYRP1抗原的完全人類抗體及嵌合抗體，TA99係對TYRP1具有特異性之鼠科動物抗體。本發明進一步提供編碼及表現該等抗體之聚核酸及宿主細胞。本發明亦提供在哺乳動物中調節TYRP1活性、治療癌細胞生長、及治療惡性黑色素瘤之方法，其藉由單獨或與抗癌劑或治療組合投與有效量之抗體。
