Siva Ram Kiran VAKA,Dipen DESAI,Wantanee PHUAPRADIT,Navnit H. SHAH,Kanji MEGHPARA
申请号：
US15128818
公开号：
US20170173157A1
申请日:
2015.03.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are methods of making oral pharmaceutical compositions that contain substantially crush resistant drug containing microparticles. The microparticles may contain an active pharmaceutical agent, a polymer and a plasticizer. The microparticles may be un-coated (so as to impart an immediate release profile) or coated so as to impart an extended release (ER), delayed release (DR) or delayed extended release (DER) profile. One or more of the populations of microparticles may be coated with a taste masking composition. The methods may produce oral compositions such as orally disintegrating tablets that contain one or more these types of microparticles in order to further customize the release profile. Also disclosed are the oral compositions, per se, and methods of using same for their intended purposes.
