Production of latanoprostene bunod by gravity column chromatography, in optional, previously definied quality

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专利权人:

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt.

发明人:

Takacs Laszlo,Fekete Ibolya,Buzder-Lantos Peter,Laszlofi Istvan,Hortobagyi Iren,Havasi Gabor,Dr. Kardos Zsuzsanna

申请号：

HU1500594

公开号：

HU1500594A2

申请日:

2015.12.04

申请国别(地区):

HU

年份:

2017

代理人:

摘要：

The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.

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