Heteroaromatic compounds as PI3 kinase modulators and methods of use thereof

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专利权人:

カリター・サイエンシーズ・エルエルシー;サンシャイン・レイク・ファーマ・カンパニー・リミテッド;カリター・サイエンシーズ・エルエルシー

发明人:

シ、ニン

申请号：

JP2015541973

公开号：

JP6268183B2

申请日:

2013.11.10

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The present invention provides heteroaromatic derivatives of formula (I) and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/