Magnuson, Steven R,Rawson, Thomas E,Zak, Mark E,Liu, Wendy,Mendonca, Rohan,Pastor, Richard,Lyssikatos, Joseph P,Siu, Michael,Gibbons, Paul,Zhou, Aihe,Zhu, Bing-Yan,Hanan, Emily
申请号：
NZ73877810
公开号：
NZ738778A
申请日:
2010.07.02
申请国别(地区):
NZ
年份:
2019
代理人:
摘要：
Disclosed are pyrazolopyrimidine compounds of formula (I) and methods for their preparation. In particular the compound is N-(5-(5-chloro-2-methoxyphenyl)-1-(cyanomethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide. The compounds of formula (I) are Janus kinase (JAK) inhibitors, and useful for treating cancer, polycythemia vera, essential thrombocytosis, myelofibrosis, chronic myelogenous leukemia (CML), rheumatoid arthritis, inflammatory bowel syndrome, Chron’s disease, psoriasis, contact dermatitis or delayed hypersensitivity reactions.
