A system and a method of constructing a personalized or patient specific neural stimulation model. The method includes measuring an electro-physiology signal of an individual and establishing a personalized or patient specific neural stimulation model that has a preset model parameter and generates a human physiology parameter according to the model parameters； and analyzing the human physiology parameters and regulating the model parameters according to a parameter-optimizing algorithm, such that the human physiology parameters outputted by the personalized or patient specific neural stimulation model matches the measured electro-physiology signal.
