It refers to a human reproduction protein (ids-b) for the effective treatment of Hunter sindrome, that is, the composition and method of isobutylene - β isobutylene (ICV) in the brain. It also refers to effective ways to reduce symptoms not only in the brain and spinal cord, but also in peripheral tissues including the liver, spleen and kidney.Se refiere a composiciones y metodos para la administracion intracerebroventricular (ICV) de idursulfasa-beta (IDS-B), una proteina iduronato- 2-sulfatasa recombinante humana, para el tratamiento eficaz del Sindrome de Hunter. Tambien se refiere a metodos que reducen eficazmente los sintomas no solo en el cerebro y la medula espinal sino tambien en los tejidos perifericos que incluyen higado, bazo y rinon.