Relates to compositions and Methods for the Administration intracerebroventricular (ICV) idursulfase (IDS (beta), a Protein Recombinant human iduronate-2-sulfatase,For the effective treatment of Hunter Syndrome.It also refers to methods that effectively reduce the symptoms not only in the Brain and Spinal Cord, but also in Peripheral tissues, including liver, Spleen and Kidney.Se refiere a composiciones y metodos para la administracion intracerebroventricular (ICV) de idursulfasa-beta (IDS-B), una proteina iduronato- 2-sulfatasa recombinante humana, para el tratamiento eficaz del Sindrome de Hunter. Tambien se refiere a metodos que reducen eficazmente los sintomas no solo en el cerebro y la medula espinal sino tambien en los tejidos perifericos que incluyen higado, bazo y rinon.