TANIGUCHI, TAKAHIKO,YOSHIKAWA, MASATO,MIURA, KASEI,HASUI, TOMOAKI,HONDA, EIJI,IMAMURA, KEISUKE,KAMATA, MAKOTO,KAMISAKI, HARUHI,QUINN, JOHN F.,RAKER, JOSEPH,CAMARA, FATOUMATA,WANG, YI
申请号：
PE0024932012
公开号：
PE03462013A1
申请日:
2011.06.22
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to FUSED Heterocyclic compounds of formula (i) where a is a Ring of six members Z1, Z2, Z3 and Z4 are each - - ch = n = o or s and, among others, methylene, R is a compound of formula (i) or (ii) where R1 and R2 are Each phenyl and Heterocyclic 5 to 10 members l is s, or, - CO - OCH2 - among others, B1 and B2 are each benzene, pyridine, pyrazine, pyrimidine,Among others d is a Ring of 5 or 6 members.Preferred compounds are: 1 - ethyl - 4 - methyl - 3 - (4 - (3 - [methyl 3h imidazo [4,5-b] pyridin-2-yl) oxy] phenyl) - 2H - 1,3 Dihydro imidazo [4,5-b] pyridin - 2 - 1 - ethyl - One 6 - methoxy - 3 - (4 - (3 - [methyl 3h imidazo [4,5-b] pyridin-2-yl) oxy] phenyl) - 2H - 1,3 Dihydro imidazo [4,5-b] pyridin - 2 - One 1.7 - dimethyl - 3 - (4 - [(3 Methyl 3h imidazo [4,5 - - B] pyridin-2-yl) oxy] phenyl) - 2H - 1,3 Dihydro imidazo [4,5-b] pyridin - 2 - One among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of phosphodiesterase 10a (pde10a) being useful in the treatment of schizophrenia, autism, Alzheimers diseaseSE REFIERE A COMPUESTOS HETEROCICLICOS FUSIONADOS DE FORMULA (I) DONDE A ES UN ANILLO DE 6 MIEMBROS Z1, Z2, Z3 Y Z4 SON CADA UNO -N= O -CH= Y ES O, S, METILENO, ENTRE OTROS R ES UN COMPUESTO DE FORMULA (i) O (ii) EN DONDE R1 Y R2 SON CADA UNO FENILO O HETEROCICLICO DE 5 A 10 MIEMBROS L ES S, O, -CO-, -OCH2-, ENTRE OTROS B1 Y B2 SON CADA UNO BENCENO, PIRIDINA, PIRIMIDINA, PIRAZINA, ENTRE OTROS D ES UN ANILLO DE 5 O 6 MIEMBROS. SON COMPUESTOS PREFERIDOS: 1-ETIL-6-METIL-3-{4-[(3-METIL-3H-IMIDAZO[4,5-b]PIRIDIN-2-IL)OXI]FENIL}-1,3-DIHIDRO-2H-IMIDAZO[4,5-b]PIRIDIN-2-ONA 1-ETIL-6-METOXI-3-{4-[(3-METIL-3H-IMIDAZO[4,5-b]PIRIDIN-2-IL)OXI]FENIL}-1,3-DIHIDRO-2H-IMIDAZO[4,5-b]PIRIDIN-2-ONA 1,7-DIMETIL-3-{4-[(3-METIL-3H-IMIDAZO[4,5-b]PIRIDIN-2-IL)OXI]FENIL}-1,3-DIHIDRO-2H-IMIDAZO[4,5-b]PIRIDIN-2-ONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA 10A (PDE10A) S
