BURGER, Matthew T.,RAMURTHY, Savithri,TAFT, Benjamin R.
申请号：
PE0004452017
公开号：
PE13382017A1
申请日:
2015.09.11
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Relates to compounds of formula I, where R1 is H or CH3 R2 is pyridinyl or phenyl X and y are n o - och2chr3r4 R3 is H or Oh R4 is 2 - (Methyl or fosfonooxi fosfonooxi) Z is n or Ch.Preferred compounds are: 2 - ((4 - (2 - methyl - 5 - (2 - (trifluoromethyl) isonicotinamido) phenyl) - 6 - morfolinopiridin - 2 - il) oxy) ethyl dihydrogen phosphate (R) - 2 - ((4 - (2 - methyl - 5 - (2 - (trifluoromethyl) isonicotinamido) phenyl) - 6 - (3 - metilmorfolino) pyridin-2-yl) oxy) ethyl dihydrogen phosphate among others. It also relates to a Pharmaceutical Composition and a method of treatment.These compounds are inhibitors of RAF Kinases, being useful in the treatment of breast cancer, gastrointestinal Tumors, among othersSe refiere a compuestos de formula I, donde: R1 es H o CH3 R2 es piridinilo o fenilo X e Y son N o -OCH2CHR3R4 R3 es H u OH R4 es 2-(fosfonooxi)metil o fosfonooxi Z es N o CH. Son compuestos preferidos: 2-((4-(2-metil-5-(2-(trifluorometil)isonicotinamido)fenil)-6-morfolinopiridin-2-il)oxi)etil dihidrogeno fosfato (R)-2-((4-(2-metil-5-(2-(trifluorometil)isonicotinamido)fenil)-6-(3-metilmorfolino)piridin-2-il)oxi)etil dihidrogeno fosfato entre otros. Tambien se refiere a una composicion farmaceutica y a un metodo de tratamiento. Dichos compuestos son inhibidores de quinasas Raf, siendo utiles en el tratamiento de cancer de mama, tumores gastrointestinales, entre otros
