CORKEY, Britton,Graupe, Michael,Koch, Keith,Melvin, Lawrence S.,Notte, Gregory
申请号：
ES15151030
公开号：
ES2662397T3
申请日:
2010.07.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula I for use in the treatment of an episode of acute cardiovascular disease, wherein the compound of Formula I is co-administered with a therapeutic agent, and Formula I is: ** (See formula) ** in which: R1 is alkyl of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-10 carbon atoms, alkynyl of 2-10 carbon atoms, aryl, heteroaryl or heterocyclyl, all of which are optionally substituted with 1, 2 or 3 substituents selected from halo, oxo, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, heterocyclyl, phenyl, phenoxy, halo, -CN, -O-R6, -C ( O) -R6, -OC (O) - R6, -C (O) -O-R6, - N (R6) -C (O) -O-R7, -N (R6) -C (O) -R7 , -N (R6) -C (O) -N (R6) (R7) and -C (O) -N (R6) (R7), in which alkyl, cycloalkyl, heterocyclyl, phenyl and phenoxy are optionally substituted with 1, 2 or 3 substituents selected from alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkoxy of 1-6 atoms of carbon, hydroxyl and halo； with the proviso that R1 is not methyl when R3 is morpholinyl or furyl； wherein R6 and R7 are independently selected from the group consisting of hydrogen, alkyl of 1-6 carbon atoms or cycloalkyl of 3-8 carbon atoms； or R6 and R7 when taken together with the nitrogen to which they are attached form a heterocycle； R2 is hydrogen, halo, cyano, alkoxy or alkyl optionally substituted with halo； R3 is aryl, heteroaryl or heterocyclyl, all of which are optionally substituted with 1, 2 or 3 substituents selected from alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, haloalkoxy, oxo, -CN, -O-R6, -OC (O) -R6, -OC (O) -N (R6) (R7), -S-R6, -N (R6) (R7), -S (>； = O) -R6, -S (>； = O) 2R6, -S (>； = O) 2-N (R6) (R7), -S (>； = O) 2-O-R6, -N (R6) -C (O) -R7, -N (R6) -C (O) -O-R7, -N (R6) -C (O ) -N (R6) (R7), -C (O) - R6, -C (O) -O-R6, -C (O) -N (R6) (R7) and -N (R6) -S ( >； = O) 2-R7, in which
