A delivery system (100) having an improved handle (112) allowing operation of the delivery system with one hand while maintaining accuracy in delivery and deployment of a prosthesis in a body lumen. The delivery system includes a sheath (101) and a handle (112). The handle includes a slide shaft (108) having a threaded outer surface (116)； a hub assembly (104) coupled to the sheath, and a sliding grip (105). The hub assembly includes an inner slider (502) having a thread tooth pivot support (502A), a thread tooth (504A) pivotably mounted to the thread tooth pivot support and a sleeve (432) having a thread tooth press member (534A) pressing on the thread tooth. Motion of the sleeve relative to the inner slider pivots the thread tooth on the thread tooth pivot support to engage and disengage the hub assembly with the threaded outer surface. The sliding grip is rotatably coupled to a proximal end of the hub assembly, and the sliding grip is prevented from rotating to provide a stable grip to allow operation of the catheter with one hand.
