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Specifically glyco-substituted porphyrins and chlorins for photodynamic therapy
专利权人:
UNIVERSITÄT HAMBURG;biolitec Unternehmensbeteiligungs II AG
发明人:
KLINGENBURG René,STARK Christian B.W.,WIEHE Arno,AICHER Daniel,GRÄFE Susanna,ALBRECHT Volker
申请号:
LU101031
公开号:
LU101031B1
申请日:
2018.12.10
申请国别(地区):
LU
年份:
2020
代理人:
摘要:
The present invention provides certain tetrapyrrolic compounds having a structure of Formula 1, 2, or 3: H or O-R is a substituent in the mefa or para position of the phenyl ring, R1 is a glyco-substituent derived from a mono-, di-, or trisaccharide group, and each R2 is independently selected from the group consisting of a linear or branched (fluoro-)alkyl group with 3 to 8 carbon atoms, phenyl, pentafluorophenyl, 3,5- bis(trifluoromethyl)phenyl, 4-(1'-thio-p-D-glucosyl)-2,3,5,6-tetrafluorophenyl, 4-(1'-thio-p- D-galactosyl)-2,3,5,6-tetrafluorophenyl, mefa- or para-hydroxyphenyl, mefa- or para-carboxyphenyl, and mefa- or para-YO-phenyl with Y being a polyethyleneglycol-residue with (CH2CH2O)nCH3 with n = 1-30.
来源网站:
中国工程科技知识中心
来源网址:
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