The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R1, R2, R3, and R4are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.本發明係關於脾酪胺酸激酶抑制劑的化合物以及關於其在多種疾病狀態，包括癌症和發炎病症，的治療中的用途。在特定的實施例裡，該化合物的結構以化學式I表示：其中R1、R2、R3、以及R4是如本文中所描述的。本發明進一步提供包括化學式I的化合物、或其醫藥上可接受的鹽的醫藥組合物，以及使用這些化合物和組合物以治療由脾酪胺酸激酶介導的病症的方法。
