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High concentration antibody formulations
专利权人:
ALEXION PHARMACEUTICALS INC.
发明人:
ZHOU XIAO-HONG,WANG YI
申请号:
NZ59861012
公开号:
NZ598610A
申请日:
2012.03.07
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed is an aqueous solution comprising an anti-C5 antibody at a concentration of 40 mg/mL to 200 mg/mL, wherein the solution comprises: (i) histidine at a concentration of between 20 mM and 50 mM, inclusive of 20 mM and 50 mM; (ii) serine at a concentration of between 30 mM and 100 nM, inclusive of 30 mM and 100 mM; (iii) sorbitol at a concentration of 0.1% to 5% (w/v), inclusive of 0.1% to 5% (w/v); and (iv) at least 1% (w/v) mannitol. Also disclosed is the use of the said solution in treating a patient afflicted with a complement associated disorder.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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