Joon Sun Yoon,Hwa Jin Lee,Kye Sook Yi,Cheol Min Kim,Byung Pil Lim,Shin Jae Chang,Seung Suh Hong
申请号：
US15529828
公开号：
US20170326231A1
申请日:
2015.11.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to an epitope specific to hepatitis B virus surface antigen and a binding molecule binding to the same for neutralizing hepatitis B virus. Since the epitope provided by the present invention is produced by forming a three-dimensional structure and does not comprise a determinant, by which escape mutation is induced against an administration of existing vaccines or HBIg, a composition comprising an antibody biding to the epitope or a vaccine composition comprising the epitope has a very low possibility of causing a decrease in efficacy due to escape mutation. Therefore, such an antibody or vaccine composition can be very effectively used in prevention and/or treatment of HBV.
