A drive-control system for an injection device for delivering a set dose of a pharmaceutical substance contained in a replaceable cartridge, the system comprising a tubular housing body (2) having a longitudinal axis (A-A), a proximal end (2a) and a distal end (2b), the system further comprising a helical spring (7) contained in the housing body and a piston rod (5) provided with an external thread, the piston rod (5) being moveable towards said distal end (2b). The housing body (2) further contains (i) a driving sleeve (10) having a distal edge (10b), the driving sleeve (10) being rotatable around the axis (A-A) of the housing body (2) and slidable along said axis, the helical spring (7) being placed over the driving sleeve (10), (ii) a blocking sleeve (12) having a proximal edge (12a), the blocking sleeve (12) being stationary relative to the housing body (2) and (iii) a guiding sleeve (11) having a proximal edge (11a), the guiding sleeve (11) being located within the blocking sleeve (12) and being rotatable around the axis (A-A) of the housing body (2) and blocked in translation along said axis. Rotation of the driving sleeve (10) in a first direction by a defined angle causes its translation towards the proximal end (2a) of the housing body (2) and compression of the spring (7), with the distal edge (10b) of the driving sleeve (10) sliding on the proximal edges (11a, 12a) of the guiding sleeve (11) and the blocking sleeve (12). Rotation of the driving sleeve (10) in a second direction by the same angle, causing its translation towards the distal end (2b) of the housing body (2), is triggered by extension of the spring (7) and during the rotation of the driving sleeve (10) in the second direction the distal edge (10b) of the driving sleeve (10) is sliding only on the proximal edge (12a) of the blocking sleeve (12) causing the guiding sleeve (11) to rotate in the second direction and the piston rod (5) to move axially in the distal direction. A device comprising t
