The present invention discloses a system for the administration of a plasma modified field (PMF) to a subject comprising: (a) a non thermal plasma (NTP) emitting source for emitting a plasma beam (b) a plasma modified field coupling mechanism (PMFCM) comprising a plasma beam dish having at least one opening for the passage of said plasma beam said plasma beam dish having a first surface and a second opposite surface and (c) a controller for controlling said PMFCM. In a main aspect of the invention, said first surface of said plasma beam dish is mounted with: (i) at least one coupling element selected from the group consisting of: (1) at least one ferroelectric element for providing said field (2) at least one ferromagnetic element for providing said field (3) at least one piezoelectric element for providing said field and (4) at least one piezomagnetic element for providing said field and (ii) at least one reflecting element. In a further main aspect, the PMFCM and said controller are configured to adjust any of said at least one coupling and reflecting element in a predetermined manner thereby providing said PMF for inducing a therapeutic or regenerative or beneficial effect on said subject. The present invention further discloses methods and use of the aforementioned system.