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Aryl-pyridine derivatives as aldosterone synthase inhibitors
专利权人:
NOVARTIS AG
发明人:
ALLAN, MARTIN,CHAMOIN, SYLVIE,HU, QI-YING,IMASE, HIDETOMO,PAPILLON, JULIEN
申请号:
ES10785016
公开号:
ES2551002T3
申请日:
2010.11.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of Formula I: ** Formula ** wherein: A is phenyl, naphthyl or benzofuranyl; R1 for each presence is independently halogen, C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkoxy, S-C1-6-alkyl, - SC6-10-aryl, C6-10-aryl, C6- 10-Cyl-C1-6-alkyloxy, heteroaryl, heterocyclyl, C6-10aryloxy, heteroaryloxy, heterocyclyloxy, cyano, NRaRb, nitro, C (O) -C1-6-alkyl, C (O) O-C1-6-alkyl, C (O) O-C6-10aryl, C (O) O-heteroaryl, C (O) NRaRb, NRaC (O) - C1-6-alkyl, NRaC (O) -C6-10-aryl, NRaC (O) - heteroaryl, NRa-heterocyclyl, carboxy, sulfonyl, sulfamoyl or sulfonamido, in which each alkyl, alkoxy, aryl, heteroaryl and heterocyclyl are optionally substituted with halo, C1-6-alkyl, C1-6-alkoxy, hydroxy, halo-C1 -6-alkyl, C6-10-aryl, heteroaryl, C6-10-aryloxy or C3-7cycloalkyl; Ra and Rb for each presence, independently H, C1-6-alkyl, C3-7-cycloalkyl, C6-10-aryl, heterocyclyl, heteroaryl or Ra and Rb to which they are attached to the same nitrogen, can form together with the nitrogen to which a saturated 5- to 7-membered heterocyclyl R2 is attached is H, C1-6-alkyl, C1-6-alkoxy, halo-C1-6-alkyl or halogen; R3 and R4 are independently H, C1-6-alkyl or C3-7cycloalkyl; wherein alkyl may be optionally substituted with C1-6-alkoxy, halogen, hydroxy, or R3 and R4 may form together with the atoms to which a 4 to 7 membered heterocyclyl or a 3 to 7 membered cycloalkyl are attached; and when A is naphthyl then one of R3, R4 is different from H; R5 is H or C1-6-alkyl; or R5 and R3 or R5 and R4 form together with the atoms to which a saturated 4- to 7-membered heterocyclyl is attached; or R5 and R2 together with the atoms to which a saturated 5- to 7-membered ring heterocyclyl are attached which may be optionally substituted with oxo; n is 0, 1, 2, 3, 4 or 5; with the proviso that the compound of Formula I is not (3-o-toluylpyridin-4-yl) methanol; (3-methoxy-5-phenylpyridin 4- yl) methanol, (3- (2-fluorophenyl)) - 5-methoxypyridin-4-yl) methanol, (3- (4-fluorophenyl)) - 5-methoxypyridin-4-yl) meth
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