A compound of Formula I: ** (See formula) ** wherein: A is a heteroaryl selected from the group consisting of benzimidazolyl, azaindolyl, quinolinyl, benzothienyl, benzoxazolyl, thienyl and benzothiazolyl； R1 for each presence is independently halogen, C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkoxy, S-C1-6-alkyl, - SC6-10-aryl, C6-10-aryl, C6- 10-aryl-C1-6-alkyloxy, heteroaryl, heterocyclyl, C6-10aryloxy, heteroaryloxy, heterocyclyloxy, cyano, NRaRb, nitro, C (O) -C1-6-alkyl, C (O) O-C1-6-alkyl , C (O) O-C6-10aryl, C (O) O-heteroaryl, C (O) NRaRb, NRaC (O) - C1-6-alkyl, NRaC (O) -C6-10-aryl, NRaC (O ) -heteroaryl, NRa-heterocyclyl, carboxy, sulfonyl, sulfamoyl or sulfonamido, in which each alkyl, alkoxy, aryl, heteroaryl and heterocyclyl are optionally substituted with one or more groups selected from the group consisting of halo, C1-6-alkyl , C1-6-alkoxy, hydroxy, halo-C1-6-alkyl, C6-10-aryl, heteroaryl, C6-10-aryloxy and C3-7cycloalkyl； Ra and Rb for each presence, independently H, C1-6-alkyl, C3-7-cycloalkyl, C6-10-aryl, heterocyclyl, heteroaryl or Ra and Rb to which they are attached to the same nitrogen, can form together with the nitrogen to which a saturated 5- to 7-membered heterocyclyl R2 is attached is H, C1-6-alkyl, C1-6-alkoxy, halo-C1-6-alkyl, C3-7-cycloalkyl, cyano, or halogen； R3 and R4 are independently H, C1-6-alkyl or C3-7cycloalkyl； wherein alkyl may be optionally substituted with C1-6-alkoxy, halogen, hydroxy, or R3 and R4 may form together with the atoms to which a 4 to 7 membered heterocyclyl or a 3 to 7 membered cycloalkyl are attached； and when A is benzothiazolyl then one of R3, R4 is different from H； R5 is H or C1-6-alkyl； or R5 and R3 or R5 and R4 form together with the atoms to which a saturated 4- to 7-membered heterocyclyl is attached； or R5 and R2 together with the atoms to which a saturated 5- to 7-membered ring heterocyclyl are attached which may be optionally substituted with oxo； n is 0, 1, 2, 3, 4 or 5； or a pharmaceutically acceptable
