Andrei Konradi,Stephen S. Dominy,Casey C. Lynch,Craig Coburn,Joseph Vacca
申请号：
US15975490
公开号：
US20180334440A1
申请日:
2018.05.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
