Catherine McLellan,Ralph Mazitschek,Luke Whitesell,Susan L. Lindquist
申请号：
US14408605
公开号：
US09505735B2
申请日:
2013.06.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides compounds of Formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting fungal or parasitic growth. The compounds are useful as inhibitors of glycosylphosphatidylinositol (GPI)-anchor biosynthesis, in particular, as inhibitors of fungal Gwt1 activity. The present invention further provides methods of using the compounds described herein for treating fungal or parasitic infections. The compounds can also be used as biological probes to study the effects of inhibiting Gwt1 activity.
