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NOUVEAUX DÉRIVÉS D'ARYLQUINOLÉINE
专利权人:
F.HOFFMANN-LA ROCHE AG
发明人:
申请号:
EP12780486.2
公开号:
EP2773619B1
申请日:
2012.10.29
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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