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NEW ARYL-QUINOLINE DERIVATIVES
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CECCARELLI, SIMONA M.,CONTE, AURELIA,KUEHNE, HOLGER,KUHN, BERND,NEIDHART, WERNER,OBST SANDER, ULRIKE,RUDOLPH, MARKUS
申请号:
SG11201401937Y
公开号:
SG11201401937YA
申请日:
2012.10.29
申请国别(地区):
SG
年份:
2014
代理人:
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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