A process for obtaining compositions constituted by propolis nanoparticles is disclosed. The nanoparticles are optionally associated to a substance of interest such as active ingredients, and, optionally, substances of secondary effect such as synergists and adjuvants. The process includes preparing a fraction A, which consists of propolis extract dissolved in an organic solvent, to which stabilizer and/or emulsifier may be added, and, optionally, substances of interest and/or of secondary effect； ii) preparing a fraction B, aqueous phase, constituted by: (ii.1) water； or (ii.2) an aqueous solution or dispersion, to which stabilizer and/or emulsifier may be added； (iii) dropping the fraction A onto the fraction B or vice versa； iv) homogenizing the mixture by stifling and spontaneous formation of nanoparticles with average size from 1 to 1000 nm in a dispersion； and v) optionally (v-1) removing organic solvent and/or (v-2) drying the nanodispersion.
