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Non-aqueous compositions for oral delivery of insoluble bioactive agents
专利权人:
Doron Friedman
发明人:
Doron Friedman
申请号:
US10585298
公开号:
US08187615B2
申请日:
2004.12.19
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a composition of low water solubility drug, dissolved or dispersed in a non crystalline or low crystalline form in an emulsion type composition of internal oily-solvent and external non-hydrous and water soluble solvent, whereas 1) emulsifying stabilizer comprises low fraction of the composition, and 2) emulsions of mean droplets size below one micron is obtained upon dilution with physiological fluids, and 3) facilitated dispersion of biologically active agents in body fluids is obtained, and more particularly to facilitating biological availability or improving clinical performance.
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