AstraZeneca UK Limited;Bristol-Myers Squibb Company
发明人:
Narang, Ajit,Rao, Venkatramana M.,Desai, Divyakant S.
申请号：
AU2011295837
公开号：
AU2011295837B2
申请日:
2011.09.01
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage.
