Refers to tiadiazoles and Oxadiazoles derivative compounds of formula (i) where u is n or o or NH D, or a Link n is 0 to 3 p is 0 to 2 W is c or N X is s or u, R1, R2, R3 and R4 are each h,Alkyl (C1 - C6) or R1 and R2 are next to the carbon Atom to which they are attached a cycloalkyl (C3 - C10) or R3 and R4 are next to the carbon Atom to which they are attached a cycloalkyl (C3 - C10) and is H, alkyl (C1 - C6), cicloalquil (C3 - - oxilo cycloalkyl (C10) C3 - C10), among others R is H or Halogen Z1 e Sta is absent or s, - NH, - NHC (or S), (- CH2 -),Among others, Z2 is absent or methylene Z3 is absent or or or methylene Z4 is absent or is H or C shape with Z3 a cycloalkyl (C3 - C10) R5 is H, heterocicloalquilalquilo (C1 - C6 alkyl, optionally substituted with hydroxyl), among others.Preferred compounds are acid: {4 - [4 - (5 - [1,3,4] thiadiazole - Benzyl - 2 - phenyl]} ilcarbamoil) cyclohexyl acetic acid cis - 4 - [4 - (5 - [1,3,4] thiadiazole - Benzyl - 2 - ilcarbamoil 2-chlorophenoxy) - cyclohexane carboxylic acid (Trans -) - {4 - [4 - (5 - [1,3,4] bencilsulfanilmetil - tiadiazol - 2 - phenyl Cyclohexyl acetic ilcarbamoil)]} Among others. It also relates to a preparation method and a Pharmaceutical composition.These compounds inhibit the biosynthesis of triglycerides to be useful in the treatment of Obesity, dyslipidemia, fatty liver, Type 2 diabetes, metabolic syndromeSE REFIERE A COMPUESTOS DERIVADOS DE TIADIAZOLES Y OXADIAZOLES DE FORMULA (I) DONDE U ES N U O D ES O, NH O UN ENLACE n ES DE 0 A 3 p ES DE 0 A 2 W ES C O N X ES S U O R1, R2, R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6) O R1 Y R2 FORMAN JUNTO AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS UN CICLOALQUILO(C3-C10) O R3 Y R4 FORMAN JUNTO AL ATOMO DE CARBONO AL QUE ESTAN UNIDOS UN CICLOALQUILO(C3-C10) Y ES H, ALQUILO(C1-C6), CICLOALQUIL(C3-C10)-OXILO CICLOALQUILO(C3-C10), ENTRE OTROS R ES H O HALOGENO Z1 ESTA AUSENTE O ES S, -NH, -NHC(O), -S(O)-CH2, ENTRE OTROS Z2 ESTA AUSENTE O ES METILENO Z3 ESTA AUSENTE O ES O
