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1-(3-AMINOPROPYL)-SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
专利权人:
CHAJNIZ EKEDEMI OF SAJENSIZ;SHANKHAJ INSTITYUT OF MATIRIA MEDIKA
发明人:
LYU Khun (CN),ЛЮ Хун (CN),U Bejli (CN),У Бэйли (CN),CHZHEN Yuntan (CN),ЧЖЭН Юнтан (CN),SE Sin (CN),СЕ Син (CN),TSZYAN Khualyan (CN),ЦЗЯН Хуалян (CN),PEN Panfen (CN),ПЭН Паньфэн (CN),LO Zhunkhua (CN),Л
申请号:
RU2016130446
公开号:
RU0002671179C2
申请日:
2014.12.29
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I wherein W is -CH2CH2-; X is N or CR6; R1 is selected from 5-6 membered heteroaryl, unsubstituted or substituted with 1 to 3 substituents, wherein said heteroaryl contains from 1 to 2 heteroatoms selected from a sulphur or nitrogen atom, and each of said substituents is independently selected from a halogen atom, straight or branched C1-C4 alkyl, straight or branched C1-C4 alkoxy, -NR10R11, -C(=O)R12, straight or branched C1-C4 alkanoyloxy, cyano, nitro, or two adjacent substituents together with the attached carbon atom form a 6-membered aromatic ring, a 5-membered saturated ring or a 5-membered heterocyclic ring containing 2 heteroatoms selected from an oxygen atom; R2 is selected from the following groups, unsubstituted or substituted with 1 to 3 substituents: straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, a 6-membered heterocyclic group containing 1 heteroatom selected from a nitrogen atom, C6-aryl; wherein said substituent is selected from the group consisting of a halogen atom, straight or branched C1-C4 alkyl, straight or branched C1-C4 alkylsulphonyl group, tetrazolyl, cyano; each of R3, R4 and R5 is independently selected from the group consisting of H, straight or branched C1-C6 alkyl; values of other radicals are given in the patent claim. Invention also relates to a production method, a pharmaceutical composition and to the use of the compound. .EFFECT: technical result: obtaining novel compounds of formula I, which have the properties of a CCR5 antagonist and can be used to treat human immunodeficiency virus (HIV) infection.10 cl, 13 tbl, 181 exИзобретение относится к соединению формулы I, в которой W представляет собой -СН2СН2-; X представляет собой N или CR6; R1 выбран из 5-6-членного гетероарила, незамещенного или замещенного от 1 до 3 заместителями, где указанный гетероарил содержит от 1 до 2 гетероатомов, выбранных из атома серы или азота, и каждый из указанных заместителе
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